Votrient 200MG TABLET (Pazopanib Tablets) | Apple pharmaceuticals
Votrient 400 mg is a type of protein kinase inhibitors, the main ingredient which is used as pazopanib. It is also indicated Votrient 400 mg tablet for the treatment of advanced kidney cancer and soft tissue sarcoma Votrient 400mg is an antineoplastics medication which interferes with the development and spreads of cancer cells in the body.
USAGE
Votrient 400 mg tablet is used as a single agent to treat the renel cell carcinoma and its advanced stage It works by preventing the activity of proteins which are interferes with the growth and spread of cancer cells.Votrient 400 mg tablet is also used as a single regimen to treat the Soft Tissue Sarcoma, (a type of cancer that occurs in the supportive tissue of the body). The cancer can develop in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs.
PHARMACOLOGY
Votrient 400 mg belongs to an inhibitor of potent protein kinase and selective multiple receptor tyrosine kinases (RTKs) which are described in beginning of signal transduction pathways that ready for proliferation of tumor cells and affect growth critical to cell continuity and tumor progression. RTKs comes in the blockage and involves the receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β), and stem cell factor.
DOSAGE AND ADMINISTARTION
Votrient 400 mg dosage for renal cell carcinoma and soft tissue sarcoma (cancer in joints, muscle) will be initially 800mg , the dose adjustment in 200mg increments or decrements dose based on tolerance but max dose in adult is 800mg/day. Moderate total bilirubin >1.5 to 3 times, Votrient dose of 200mg once daily. Votrient 400 mg hould be taken on a empty stomach (1hr before or 2hr after meals. Swallow the medicine whole don’t chew/crush. Food interaction :Avoid grapefruit juice or grapefruit juice.
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| Votrient 400mg |
SIDE EFFECTS
Votrient 400 mg has certain side effects, If any of the symptoms occrs or not cured then call the doctor immediately Major side effects: Diarrhae; High blood pressure; low WBC; Elevated liver function test; Blood test abnormalities; increased in bilirubin levels. Common Side effects: Nausea; loss of appetite; fatigue; blood test abnormalities (low magnesium, low glucose); weakness, stomach ache.
LACTATION
Votrient 400 mg usage is not usually given during in pregnant women and the some doctors advice to either discontinue breastfeeding or the drug, in order to give importance of drug to the mother. The drug elimination into human milk and effects in the newborn baby is unknown.
OVERDOSAGE
there is no specific antidote for Votrient 400 mg overdose, the drug doses upto 2000 mg can be administrated and It is check out in clinical trials and overdose treatment with Votrient 400 mg should consist of supportive measures.
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